L‐type Ca 2+ (Ca L ) Channels are Silent During Depolarization of Venous Smooth Muscle
نویسندگان
چکیده
منابع مشابه
Intracellular Ca Silences L-Type Ca Channels in Mesenteric Veins Mechanism of Venous Smooth Muscle Resistance to Calcium Channel Blockers
Rationale: Calcium channel blockers (CCBs) exert their antihypertensive effect by reducing cardiac afterload but not preload, suggesting that Ca influx through L-type Ca channels (LTCC) mediates arterial but not venous tone. Objective: The object of this study was to resolve the mechanism of venous resistance to CCBs. Methods and Results: We compared the sensitivity of depolarization (KCl)-indu...
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The rabbit inferior vena cava (IVC) is a large-capacitance vessel that displays typical contractile dose-response curves for caffeine and phenylephrine (PE). Using confocal microscopy on the endothelium-denuded IVC, we undertook experiments to correlate these whole-tissue contractile dose-response curves with changes in subcellular [Ca]i signals in the in situ vascular smooth muscle cells (VSMC...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2010
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.24.1_supplement.576.1